155742-48-6

Basic information

• Product Name: 4-OXAZOLEMETHANOL
• Synonyms: 4-OXAZOLEMETHANOL;1,3-Oxazol-4-ylmethanol;4-(Hydroxymethyl)-1,3-oxazole;4-hydroxymethyloxazole;(oxazol-4-yl)Methanol
• CAS NO: 155742-48-6
• Molecular Formula: C₄H₅NO₂
• Molecular Weight: 99.088
• Mol File: 155742-48-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 213℃
• Flash Point: 83℃
• Appearance: /
• Density: 1.250
• Vapor Pressure: 0.101mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: 2-8°C
• PKA: 13.11±0.10(Predicted)
• CAS DataBase Reference: 4-OXAZOLEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-OXAZOLEMETHANOL(155742-48-6)
• EPA Substance Registry System: 4-OXAZOLEMETHANOL(155742-48-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 155742-48-6(Hazardous Substances Data)

Usage

General Description

4-Oxazolemethanol, also known as 4-hydroxymethyl-1,3-oxazole, is a heterocyclic compound that contains both oxygen and nitrogen atoms in its five-membered ring structure. It is used as a building block in the synthesis of pharmaceuticals and agrochemicals. 4-Oxazolemethanol has also been studied for its potential biological activities, including antimicrobial, anticancer, and antiviral properties. It is a versatile intermediate in organic chemistry and is often used in the development of new chemical compounds for various applications. Its unique structure and reactivity make it a valuable and important chemical in the field of chemical synthesis and drug discovery.

InChI:InChI=1/C4H5NO2/c6-1-4-2-7-3-5-4/h2-3,6H,1H2

Upstream product

• 170487-38-4 methyl 4.-oxazolecarboxylate 
• 460081-18-9 ethyl 2-chloro-1,3-oxazole-4-carboxylate 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 118994-84-6 1,3-oxazole-4-carboxaldehyde 

Downstream Products

• 1065073-37-1 4-(bromomethyl)-1,3-oxazole 
• 118994-84-6 1,3-oxazole-4-carboxaldehyde 
• 214550-86-4 4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-1,3-oxazole 

Relevant articles and documents

Synthesis and orthogonal functionalization of oxazolo[5′,4′:4,5]pyrano[2,3-b]pyridine by intra- and intermolecular Pd-catalyzed direct C-H bond heteroarylation

The construction and subsequent orthogonal functionalization of a hitherto unknown oxazolo[5′,4′:4,5]pyrano[2,3-b]pyridine are reported. A palladium-catalyzed direct C-H bond functionalization methodology was used to build the tricyclic scaffold as well as to achieve the subsequent C-H bond functionalization at the C-2 position of the oxazole unit with various (hetero)aryl iodides. Remarkably, selective C-H construction and functionalization procedures preserve the chorine atom on the pyridine moiety offering a late-stage substitution site to progress drug design.

AMINOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described herein.

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.