155778-36-2

Basic information

• Product Name: 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-4-one
• Synonyms: 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-4-one
• CAS NO: 155778-36-2
• Molecular Formula: C7H9N3OS
• Molecular Weight: 183.23
• Mol File: 155778-36-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 540.6±29.0 °C(Predicted)
• Appearance: /
• Density: 1.393±0.06 g/cm3(Predicted)
• PKA: 13.91±0.20(Predicted)
• CAS DataBase Reference: 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-4-one(155778-36-2)
• EPA Substance Registry System: 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[5,4-c]azepin-4-one(155778-36-2)

Safety Data

• Hazardous Substances Data: 155778-36-2(Hazardous Substances Data)

Usage

Class

Thiazole derivative

Molecular weight

182.24 g/mol

Biological activities

anti-cancer, anti-inflammatory, anti-bacterial

Uses

building block in organic compound synthesis

Importance

potential pharmaceutical importance

Research interest

unique structure and properties for further research in medicinal chemistry and drug discovery

Upstream product

• 17583-10-7 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one 

Relevant articles and documents

BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF DERIVATIVES OF BENZOTHIAZOLONE, THIAZOLOAZEPINONE, AND FURAZANOAZEPINONE

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