15579-01-8

Usage

Uses

Used in Organic Synthesis:
Ethanol, 2-[(2-aminoethyl)dithio]is used as a reagent in organic synthesis for its ability to form strong covalent bonds with other molecules, enabling the creation of complex organic molecules.
Used in Chemical Research:
Ethanol, 2-[(2-aminoethyl)dithio]is utilized in chemical research to study its properties and potential applications in various fields.
Used in Pharmaceutical Production:
Ethanol, 2-[(2-aminoethyl)dithio]is used as a reagent in the production of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Industrial Applications:
Ethanol, 2-[(2-aminoethyl)dithio]has a variety of applications in the industrial field, including the production of chemical compounds and materials that require strong covalent bonding.

Upstream product

• 71899-86-0 S-<(3-carboxy-4-nitrophenyl)thio>-2-aminoethanethiol 
• 60-24-2 2-hydroxyethanethiol 

Relevant academic research and scientific papers

5-(2-Aminoethyl)dithio-2-nitrobenzoate as a more base-stable alternative to ellman's reagent

(Chemical Equation Presented) 5-(2-Aminoethyl)dithio-2-nitrobenzoate (ADNB) reacts with free thiols with kinetics similar to those of Ellman's reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman's reagent for the quantitation of thiol contents and enzymatic assays under basic pH conditions.

A kinetic approach to characterize the electrostatic environments of thiol groups in proteins

In this study, we synthesized a zwitterionic DTNB derivative, 5-(2- aminoethyl)-dithio-2-nitrobenzoate (ADNB), and characterized its reactions with several cationic, anionic, and neutral thiols. Reactions with ADNB, unlike those with DTNB, are relatively insensitive to electrostatic environments and ionic strengths. At relatively low ionic strength, rate ratios, k(ADNB)/k(DTNB), varied from 0.22 for reactions with low-molecular- weight cationic thiols to 3.0 for those with low-molecular-weight anionic thiols. A k(ADNB)/k(DTNB) ratio of ~200 for Cys-34 of BSA appears to reflect a very anionic environment. k(ADNB)/k(DTNB) ratios of ~6 and ~1, respectively, for canine and equine serum albumins, which have Glu-82 → Asp and Glu-82 → Ala substitutions suggest Glu-82 is the most important anionic residues affecting the reactivity of Cys-34 in BSA. k(ADNB)/k(DTNB) ratios appear to be useful for characterizing electrostatic environments of thiol groups in proteins.