155797-02-7

Basic information

• Product Name: (S)-3-Methylpiperidine hydrochloride
• Synonyms: (S)-3-Methylpiperidine hydrochloride;(S)-3-METHYLPIPERIDINE HCL
• CAS NO: 155797-02-7
• Molecular Formula: C6H14ClN
• Molecular Weight: 135.63506
• Mol File: 155797-02-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 193.1-193.3 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-3-Methylpiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Methylpiperidine hydrochloride(155797-02-7)
• EPA Substance Registry System: (S)-3-Methylpiperidine hydrochloride(155797-02-7)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 155797-02-7(Hazardous Substances Data)

Usage

General Description

"(S)-3-Methylpiperidine hydrochloride is a chemical compound that is often used in scientific research, particularly in the field of organic chemistry. It exists as a white or off-white crystalline powder and is highly soluble in water. Structurally, this compound belongs to a class of organic compounds known as piperidines, characterized by a piperidine ring, which is a six-membered heterocyclic ring containing one nitrogen atom. In this particular compound, one hydrogen atom in the piperidine ring is substituted by a methyl group. The "(S)" in the name indicates a particular spatial configuration of the molecule, as determined by the rules of stereochemistry. The hydrochloride refers to the presence of a hydrochloric acid molecule, which makes the chemical a salt, enhancing its solubility in water.

Upstream product

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Relevant articles and documents

A mild procedure for the reduction of pyridine N-oxides to piperidines using ammonium formate

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Asymmetric synthesis of chiral N-sulfinyl 3-alkyl- and 3-arylpiperidines by α-alkylation of N-sulfinyl imidates with 1-chloro-3-iodopropane

α-Alkylation of N-sulfinyl imidates with 1-chloro-3-iodopropane successfully led to 2-substituted N-tert-butanesulfinyl-5-chloropentanimidates in acceptable diastereomeric ratios (dr 67/33 to 72/28) and good yields (74-86%). Subsequent reduction with NaBH4 led to the corresponding 2-substituted N-tert-butanesulfinyl-5-chloropentylamines, which could be cyclized to a range of new chiral 3-substituted N-tert-butanesulfinylpiperidines using NaH in DMSO. Finally, the N-tert-butanesulfinylpiperidines could be efficiently deprotected to enantiomerically pure 3-alkyl- and 3-arylpiperidine hydrochlorides.

METHOD FOR SYNTHESISING OPTICALLY ACTIVE PIPERIDINES BY THE HYDROGENATION OF OPTICALLY ACTIVE PYRIDINES

The invention relates to a method for preparing optically active piperidines by the hydrogenation of pyridines using a suitable catalyst. Said method enables the preparation of a plurality of piperidine derivatives with high optical purity and in high yields.