1558002-53-1Relevant articles and documents
Palladium-Catalyzed Regioselective Synthesis of 3-(Hetero)Arylpropynamides from gem-Dibromoalkenes and Isocyanides
Salehi, Parvin,Shiri, Morteza
, p. 118 - 125 (2019)
An alternative method related to the formation of 3-(hetero)arylpropynamides using palladium/Cs2CO3, regiochemically-controlled coupling of isocyanides with 1,1-dibromo-1-alkenes is described. It was found that the presence of palladium?is crucial in the media so activated the C?Br bond in the 1,1-dibromo-1-alkenes. Subsequent isocyanide?insertion followed by reductive elimination yielded an intermediate that could be easily converted to the desired product in satisfactory yields. (Figure presented.).