1558010-54-0

Basic information

• Product Name: C₁₀H₁₁FN₂O₆
• CAS NO: 1558010-54-0
• Molecular Weight: 274.206
• Mol File: 1558010-54-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₁FN₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₁FN₂O₆(1558010-54-0)
• EPA Substance Registry System: C₁₀H₁₁FN₂O₆(1558010-54-0)

Safety Data

• Hazardous Substances Data: 1558010-54-0(Hazardous Substances Data)

Upstream product

• 122799-38-6 1-(2'-deoxy-2'-fluoro-β-D-ribofuranosyl)-5-methyluracil 

Relevant articles and documents

4′-Modified Pyrimidine Nucleosides as Potential Anti-hepatitis C Virus (HCV) Agents

Herein, we have investigated novel pyrimidine nucleosides bearing a 4'-carboxyl functionality (6-10, 13 and 15) as anti-HCV agents. In this new class of compounds, 7, 9, 10 and 15 demonstrated in vitro anti-HCV activity similar to or better than a known anti-HCV drug, ribavirin. In this work, we also, surprisingly, identified a 3'-sulfoxide analog of 3′-thiacytidine (16), obtained as a side product during the synthesis of 15, as a potent inhibitor of HCV replication at the concentration similar to that of ribavirin. No detectable in vitro cytotoxicity was observed for the investigated compounds up to the highest concentration tested.