155802-00-9

Upstream product

• 108-70-3 1,3,5-trichlorobenzene 
• 107-82-4 i-pentyl bromide 
• 2203-80-7 5-methylhex-1-yne 

Downstream Products

• 1384979-64-9 2,4,6-triisopentyl-1-nitrobenzene 
• 1384979-66-1 2,4,6-tri-(3'-methylbutyl)aniline 
• 1384979-69-4 N,N'-bis[2,4,6-triisopropylphenyl]-1,4-diaza-1,3-diene 
• 1384979-72-9 N,N'-bis-(2,4,6-triisopentylphenyl)ethylenediamine 
• 1384979-74-1 N,N'-bis-(2,4,6-triisopropylphenyl)-4,5-dihydroimidazolium chloride 
• 930301-92-1 1,3,5-tris(2-isothiocyanatoethyl)-2,4,6-tris(3-methylbutyl)benzene 
• 930301-90-9 1,3,5-tris(2-aminoethyl)-2,4,6-tris(3-methylbutyl)benzene 
• 930301-89-6 1,3,5-tris(cyanomethyl)-2,4,6-tris(3-methylbutyl)benzene 
• 930301-88-5 1,3,5-tris(chloromethyl)-2,4,6-tris(3-methylbutyl)benzene 

Relevant academic research and scientific papers

H-BPin/KOtBu Promoted Activation of Cobalt Salt to a Heterotopic Catalyst for Highly Selective Cyclotrimerization of Alkynes

A mixture of HBPin with KOtBu was found to activate cobalt salt to form a heterotopic cobalt species that is highly active for catalytic intermolecular trimerization of alkynes. This protocol affords 1,2,4-regioisomers in good yields with high regioselectivities under mild conditions. These salient features, together with the operational simplicity and high efficiency, as well as obviating the use of any costly and/or air sensitive ligands, renders the protocol promising for practical applications.

Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes

We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2] cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene molecules. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds. Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition. Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst.

Silica-supported tungsten carbynes (≡SiO)xW(≡CH)(Me)y (x = 1, y = 2; X = 2, y = 1): New efficient catalysts for alkyne cyclotrimerization

The activity of silica-supported tungsten carbyne complexes (≡SiO)xW(≡CH)(Me)y (x = 1, y = 2; x = 2, y = 1) toward alkynes is reported. We found that they are efficient precatalysts for terminal alkyne cyclotrimerization with high TONs. We also demonstrate that this catalyst species is active for alkyne cyclotrimerization without the formation of significant alkyne metathesis products. Additional DFT calculations highlight the importance of the W coordination sphere in supporting this experimental behavior.

1,3,5-Trialkyl-2,4,6-triiodobenzenes: Novel x-ray contrast agents for gastrointestinal imaging

Examination of the gastrointestinal (GI) tract has been performed for decades using barium sulfate. Although this agent has many recognized limitations including extreme radiopacity, poor intrinsic affinity for the GI mucosa, and very high density, no alternative contrast agents have emerged which produce comparable or better contrast visualization. In fact, the various techniques of the GI radiologic examination (i.e., single contrast, double contrast, biphasic) were developed to compensate for its limitations. Each of these techniques requires complex patient manipulation to achieve adequate mucosal coating or compression to overcome the marked radiopacity of barium sulfate in order to obtain a diagnostically useful examination. A series of novel radiopaque oils, the 1,3,5-trialkyl-2,4,6-triiodobenzenes, was designed to improve the efficacy, stability, and safety of barium formulations. These substances were prepared in two steps from 1,3,5- trichlorobenzene. Compound 17 (1,3,5-tri-n-hexyl-2,4,6-triiodobenzene), formulated as an oil-in-water emulsion, was found to be well-tolerated in rodents (mice, hamsters, rats) following acute oral and/or intraperitoneal administrations at 4 times the anticipated human clinical dose. No metabolism of 17 was detected in rat, hamster, dog, monkey, or human hepatic microsomes, suggesting the lack of oral toxicity was a consequence of poor absorption. In imaging experiments in dogs, emulsions of 17 have demonstrated excellent mucosal coating and improved radiodensity relative to barium sulfate suspensions. On the basis of the preliminary imaging and toxicity data, compound 17 was selected as a potential development candidate.