1558037-99-2

Basic information

• Product Name: 1,1-dichloro-2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester
• Synonyms: 1,1-dichloro-2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 1558037-99-2
• Molecular Formula: C12H17Cl2NO3
• Molecular Weight: 294.17428
• Mol File: 1558037-99-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: -2.69±0.40(Predicted)
• CAS DataBase Reference: 1,1-dichloro-2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-dichloro-2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester(1558037-99-2)
• EPA Substance Registry System: 1,1-dichloro-2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester(1558037-99-2)

Safety Data

• Hazardous Substances Data: 1558037-99-2(Hazardous Substances Data)

Usage

Chemical class

Ester

Molecular structure

Complex, containing a t-butyl group and a carbon-oxygen double bond

Biological and pharmacological properties

Known for its potential applications in the medical and agricultural industries

Derivative of

Spiroketals, a type of organic compound

Uses

Synthesis and development of pharmaceuticals and agrochemicals

Research and development

Subject of interest in the field of organic chemistry

Potential applications

Medical and agricultural industries

Upstream product

• 114214-71-0 tert-butyl 3-methylidenepyrrolidine-1-carboxylate 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 203661-71-6 6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester 
• 1239319-91-5 2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester 
• 1256240-98-8 C₁₉H₂₇NO₅S 
• 1256240-97-7 C₁₉H₂₇NO₅S 
• 1558038-60-0 C₂₇H₃₀N₆O₃ 
• 1558038-61-1 C₂₇H₃₀N₆O₃ 
• 1558038-62-2 C₂₂H₂₄N₆O₂ 
• 1558037-79-8 C₂₆H₂₆N₆O₃ 
• 1558038-67-7 C₂₅H₃₃N₅O₃ 
• 1558038-68-8 C₂₀H₂₇N₅O₂ 
• 1558037-54-9 C₂₃H₂₉N₅O₃ 
• 1558038-69-9 C₂₅H₃₃N₅O₃ 
• 1558038-70-2 C₂₀H₂₇N₅O₂ 
• 1558037-55-0 C₂₃H₂₉N₅O₃ 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.

HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS

The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.