1558038-97-3Relevant academic research and scientific papers
Rapid determination of enantiomeric excess of α-chiral aldehydes using circular dichroism spectroscopy
Barman, Sanmitra,Anslyn, Eric V.
, p. 1357 - 1362 (2014)
A method for enantiodiscrimination of α-chiral aldehydes is reported. The method utilizes circular dichroism (CD) spectroscopy and a sensing ensemble composed of 2-(1-methylhydrazinyl) pyridine (1) and Fe(II)(TfO)2. Aldehydes react rapidly with hydrazine (1) to form chiral imines, which form complexes with Fe(II). By monitoring the CD bands above 320 nm, one can determine the enantiomeric excess (ee) values of α-chiral aldehydes with an average absolute error of ±5%. The analysis was fast, and thus can have potential applications in high-throughput screening (HTS) of catalytic asymmetric induction.
