1558079-05-2Relevant academic research and scientific papers
Syntheses of hydroxamic acid-containing bicyclic β-lactams via palladium-catalyzed oxidative amidation of alkenes
Jobbins, Maria O.,Miller, Marvin J.
, p. 1620 - 1625 (2014)
Palladium-catalyzed oxidative amidation has been used to synthesize hydroxamic acid-containing bicyclic β-lactam cores. Oxidative cleavage of the pendant alkene provides access to the carboxylic acid in one step.
Diastereoselective synthesis of a hydroxamate containing bicyclo-[3.2.0] β-lactam aminal via ruthenium alkene isomerization and Pd(II)-catalyzed oxidative amidation
Jobbins, Maria O.,Majewski, Mark W.,Oliver, Allen G.,Miller, Marvin J.
supporting information, p. 3141 - 3143 (2015/02/19)
With antibiotic resistance on the rise, the need for new medicinal scaffolds is needed. The synthesis of an aminal bicyclic β-lactam core is described. The key synthetic step is Pd(II)-catalyzed oxidative amidation. The product is a single diastereomer, c
