155820-63-6

Basic information

• Product Name: benzyl 2-bromo-2,2-difluoroacetate
• Synonyms: benzyl 2-bromo-2,2-difluoroacetate
• CAS NO: 155820-63-6
• Molecular Weight: 265.054
• Mol File: 155820-63-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: benzyl 2-bromo-2,2-difluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-bromo-2,2-difluoroacetate(155820-63-6)
• EPA Substance Registry System: benzyl 2-bromo-2,2-difluoroacetate(155820-63-6)

Safety Data

• Hazardous Substances Data: 155820-63-6(Hazardous Substances Data)

Upstream product

• 38126-07-7 difluorobromoacetyl fluoride 
• 100-51-6 benzyl alcohol 
• 3832-48-2 bromodifluoroacetyl chloride 
• 667-27-6 Ethyl bromodifluoroacetate 

Downstream Products

• 351-70-2 benzyl trifluoroacetate 
• 1552321-80-8 (benzyloxycarbonyl)difluoromethyl 5-(Cbz-amino)-4-oxopentanoate 
• 350-50-5 benzyl fluoride 
• 21249-93-4 (2,2,2-trifluoroethyl)benzene 

Relevant articles and documents

Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles

We reported herein a visible light promoted difluoroalkylated cascade of imidazoles and alkenes to afford highly functionalized polycyclic imidazoles. This method features a direct radical cyclization of imidazoles with alkenes using BrCF2R as radical sources. The reaction conditions tolerate a wide range of substrate scope and afford the desired products with up to 95 % isolated yield under mild conditions. Radical-trapping and light-on/off experiments indicated a photocatalytic radical mechanism.

NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS

The present invention relates to compound of formula (I) and their use for treating bacterial infections.

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.