1558465-58-9

Basic information

• Product Name: 4-(2,3,4,5,6-pentafluorophenyl)-3-thiosemicarbazide
• Synonyms: 4-(2,3,4,5,6-pentafluorophenyl)-3-thiosemicarbazide
• CAS NO: 1558465-58-9
• Molecular Weight: 257.187
• Mol File: 1558465-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,3,4,5,6-pentafluorophenyl)-3-thiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,3,4,5,6-pentafluorophenyl)-3-thiosemicarbazide(1558465-58-9)
• EPA Substance Registry System: 4-(2,3,4,5,6-pentafluorophenyl)-3-thiosemicarbazide(1558465-58-9)

Safety Data

• Hazardous Substances Data: 1558465-58-9(Hazardous Substances Data)

Upstream product

• 35923-79-6 1,2,3,4,5-pentafluoro-6-isothiocyanatobenzene 

Relevant articles and documents

Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties

With the aim to explore the interest of the thiosemicarbazide scaffold for the inhibition of the indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target for anticancer immunotherapy, a series of 32 phenylthiosemicarbazide derivatives was prepared and their IDO inhibition evaluated. Our study demonstrated that among these derivatives, compound 14 characterized with a 4-cyanophenyl group on the thiosemicarbazide was the more potent IDO inhibitor in this series being endowed with an IC50 of 1.2 μM. The SAR depicted showed that substitution in the 3- and 4-position relative to the phenylthiosemicarbazide are very promising whereas substitution in the 2-position always leads to less potent or inactive derivatives. In fact the study highlighted a novel interesting scaffold for IDO inhibition for further development.