15585-43-0

Basic information

• Product Name: rivanicline
• Synonyms: rivanicline;But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-;Unii-6H35lf645a;(E)-Metanicotine;(E)-N-[Methyl]-4-(3-pyridinyl)-3-buten-1-aMine, RJR 2403;(3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine;trans-Metanicotine
• CAS NO: 15585-43-0
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• Product Categories: Nicotine Derivatives
• Mol File: 15585-43-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 99-101°C/0.4mm Hg
• Flash Point: 130℃
• Appearance: /
• Density: 0.980
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.03±0.10(Predicted)
• CAS DataBase Reference: rivanicline(CAS DataBase Reference)
• NIST Chemistry Reference: rivanicline(15585-43-0)
• EPA Substance Registry System: rivanicline(15585-43-0)

Safety Data

• Hazardous Substances Data: 15585-43-0(Hazardous Substances Data)

Usage

Chemical Properties

Oil

Uses

Rivanicline can be used a potential drug for the treatment of senile dementia of the Alzheimer’s type and currently being investigated as a nicotinic agonist with CNS selectivi

Upstream product

• 50-00-0 formaldehyd 
• 212332-33-7 (E)-4-(3-pyridinyl)-3-butene-1-amine 
• 312728-39-5 (3E)-N-methyl-N-(tert-butoxycarbonyl)-4-(3-pyridinyl)-3-buten-1-amine 
• 3156-52-3 3-(2-nitroethenyl)pyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 887250-41-1 E-metanicotine 3,5-dihydroxybenzoate 
• 887250-40-0 E-metanicotine 2,5-dihydroxybenzoate 

Relevant articles and documents

Dealkenylative Alkenylation: Formal σ-Bond Metathesis of Olefins

The dealkenylative alkenylation of alkene C(sp3)?C(sp2) bonds has been an unexplored area for C?C bond formation. Herein 64 examples of β-alkylated styrene derivatives, synthesized through the reactions of readily accessible feedstock olefins with β-nitrostyrenes by ozone/FeII-mediated radical substitutions, are reported. These reactions proceed with good efficiencies and high stereoselectivities under mild reaction conditions and tolerate an array of functional groups. Also demonstrated is the applicability of the strategy through several synthetic transformations of the products, as well as the syntheses of the natural product iso-moracin and the drug (E)-metanicotine.