155863-36-8

Basic information

• Product Name: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl Methanesulfonate
• Synonyms: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl Methanesulfonate;2-MaleiniMidoethyl Mesylate
• CAS NO: 155863-36-8
• Molecular Formula: C7H9NO5S
• Molecular Weight: 219.21506
• Mol File: 155863-36-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 437.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.485±0.06 g/cm3(Predicted)
• PKA: -2.45±0.20(Predicted)
• CAS DataBase Reference: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl Methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl Methanesulfonate(155863-36-8)
• EPA Substance Registry System: 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl Methanesulfonate(155863-36-8)

Safety Data

• Hazardous Substances Data: 155863-36-8(Hazardous Substances Data)

Usage

Structure

Contains a pyrrolidine ring and a methanesulfonate group

Type

Heterocyclic organic compound

Use

Intermediate in the synthesis of pharmaceutical drugs and other organic compounds

Properties

Stability and solubility in organic solvents

Applications

Commonly used in the pharmaceutical industry and academic research for the development of new drugs and compounds with potential therapeutic applications.

Upstream product

• 1585-90-6 1-(2-hydroxyethyl)-1H-pyrrole-2,5-dione 
• 7143-01-3 Methanesulfonic anhydride 
• 124-63-0 methanesulfonyl chloride 

Relevant articles and documents

Facile synthesis of indolizinoindolone, indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and isoindolopyrazinoindolone heterocycles from indole and imide derivatives

Chemo-, regio- and diastereoselective coupling reactions of indole with imide derivatives leading to unique heterocyclic systems are demonstrated. Acid-induced 3-position coupling reactions of indole with cyclic imide derived lactamols followed by acid promoted 2-position cyclizations with the corresponding aldehydes are described to obtain the indolizinoindolones and benzoindolizinoindolones. Base induced 2-position coupling reactions ofN-tosylindole withN-(2-iodoethyl)imides and the subsequent cyclizations provide indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and indolyloxazoloisoindolone. Reductive cleavage of indolyloxazoloisoindolone to the corresponding alcohol followed by mesylation and base promotedN-cyclization affords thein situair-oxidized pentacyclic product hydroxyisoindolopyrazinoindolone. A regioisomeric structural revision of the natural product from 1,2,5,6,7,11c-hexahydro-3H-indolizino[7,8-b]indol-3-one to 1,2,5,6,11,11b-hexahydro-3H-indolizino(8,7-b)indol-3-one is also reported in the present studies focussed on the methodologies for heterocyclic synthesis.

Syntheses of Reactive Fluorescent Stains Derived from 5(2)-Aryl-2(5)-(4-pyridyl)oxazoles and Bifunctionally Reactive Linkers

Several bifunctionally reactive linkers containing halide or sulfonate ester groups were prepared.The linkers were used to quaternize 5-(4-methoxyphenyl)-2-(4-pyridyl)oxazole and 2-(6-chromanyl)-5-(4-pyridyl)oxazole to produce fluorescent stains that contained a reactive group such as an isothiocyanate, an N-hydroxysuccinimidyl ester, a maleimide, or an oxirane.The stains were derivatized with either 1-propyl-amine, 1-propanethiol, or piperidine, as appropriate, to help in characteriazation.The stains may serve as more photostable alternatives to fluoresceins or coumarins.