1558787-07-7Relevant academic research and scientific papers
Facile synthesis of derivatives of 1,1,3-Trioxo-2H,4H-pyrrolo[1,2-b][1,2,4, 6]thiatriazine: A new heterocyclic system
Chen, Wenmin,Zhan, Peng,Rai, Diwakar,Huang, Boshi,Yang, Jiapei,Liu, Xinyong
, p. 495 - 501 (2013/12/04)
We reported a facile and efficient methodology to synthesize derivatives of pyrrolo[1,2-b][1,2,4,6]thiatriazine (PTTD): a new bridgehead nitrogen heterocyclic system. Treatment of methyl pyrrole-2-carboxylate with N-benzylsulfamoyl chlorides followed by subsequent hydrolysis reaction afforded 1-benzylsulfamoyl-1H-pyrrole-2-carboxylic acids, which underwent ring-closing reaction by treatment with diphenyl phosphorazidate via Curtius rearrangement; subsequent alkylation reaction afforded the desired 2,4-disubstituted-1,1,3- trioxo-2H,4H-PTTDs.
