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155897-72-6

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  • (R,S)-3-[(Tert-butyldimethylsilyl)oxy]-2-methyl-butanoic Acid Methyl Ester

    Cas No: 155897-72-6

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155897-72-6 Usage

Description

(R,S)-3-[(Tert-butyldiMethylsilyl)oxy]-2-Methyl-butanoic Acid Methyl Ester, with the CAS number 155897-72-6, is a colorless oil compound that is primarily utilized in the field of organic synthesis. Its unique chemical structure, featuring a tert-butyldiMethylsilyl group and a methyl ester, allows it to serve as a versatile building block for the creation of various complex organic molecules.

Uses

Used in Organic Synthesis:
(R,S)-3-[(Tert-butyldiMethylsilyl)oxy]-2-Methyl-butanoic Acid Methyl Ester is used as a synthetic intermediate for the development of complex organic molecules. Its application in this field is due to its unique chemical structure, which can be further modified and functionalized to create a wide range of compounds with diverse properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R,S)-3-[(Tert-butyldiMethylsilyl)oxy]-2-Methyl-butanoic Acid Methyl Ester is used as a key component in the synthesis of various drug candidates. Its ability to be easily modified and functionalized makes it a valuable asset in the development of new medications with improved efficacy and reduced side effects.
Used in Chemical Research:
(R,S)-3-[(Tert-butyldiMethylsilyl)oxy]-2-Methyl-butanoic Acid Methyl Ester is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic routes. Its unique properties and reactivity make it an ideal candidate for investigating novel chemical transformations and understanding the underlying principles governing these reactions.
Used in Material Science:
In the field of material science, (R,S)-3-[(Tert-butyldiMethylsilyl)oxy]-2-Methyl-butanoic Acid Methyl Ester can be used as a precursor for the development of new materials with specific properties. Its versatility in organic synthesis allows for the creation of novel polymers, coatings, and other materials with tailored characteristics for various applications, such as improved mechanical strength, thermal stability, or chemical resistance.

Check Digit Verification of cas no

The CAS Registry Mumber 155897-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,8,9 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 155897-72:
(8*1)+(7*5)+(6*5)+(5*8)+(4*9)+(3*7)+(2*7)+(1*2)=186
186 % 10 = 6
So 155897-72-6 is a valid CAS Registry Number.

155897-72-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (R,S)-3-[(Tert-butyldimethylsilyl)oxy]-2-methyl-butanoic Acid Methyl Ester

1.2 Other means of identification

Product number -
Other names methyl (2S,3S)-3-[tert-butyl(dimethyl)silyl]oxy-2-methylbutanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:155897-72-6 SDS

155897-72-6Downstream Products

155897-72-6Relevant articles and documents

Enantiomerically Pure Pyrrolidine Derivatives from trans-4-Hydroxy-L-proline By Electrochemical Oxidative Decarboxylation and Titanium-Tetrachloride-Mediated reaction with Nucleophiles

Renaud, Philippe,Seebach, Dieter

, p. 1704 - 1710 (1986)

Preparative electrolysis of N-methoxycarbonyl-O-hydroxyproline 4 in MeOH leads to substitution of the COOH by a MeO group (oxidative decarboxylation).The mixture 5 of the two diastereoisomers (ca. 1:1) thus obtained was reacted in CH2Cl2 with nucleophilic silylated compounds (such as allylsilane, silyl cyanide and 1-phenyl-1-silyloxyethane) or with trimethyl phosphite in the presence of TiCl4 to give 2-allyl-, 2-cyano-, 2-(2-oxo-2-phenylethyl)- and 2-phosphono-substituted hydroxypyrrolidines, respectively, with high diastereoselectivities (>= 90 percent, products 6-12).The configuration of two of the products (6/7 and 8/9) was shown to be cis.

Ring enlargement by alkylated 3-hydroxybutyrates: A synthesis of (12S, 13R)-(-)-12-methyl-13-tetradecanolide

Kraft,Tochtermann

, p. 10875 - 10882 (1995)

TBS-protected iodo alcohols 6 were prepared via Frater alkylation and applied in the synthesis of optically active macrolides 5 and 10. By ring enlargement of cyclodecanone (7) the superposition molecule 5 of two macrocyclic odorants was synthesized and a conformationally fixed tricyclic macrolide 11 constructed.

In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase

Liddle, Emma,Scott, Alan,Han, Li-Chen,Ivison, David,Simpson, Thomas J.,Willis, Christine L.,Cox, Russell J.

, p. 1727 - 1730 (2017/02/10)

Six potential diketide substrates for the squalestatin tetraketide synthase (SQTKS) dehydratase (DH) domain were synthesised as N-acetyl cysteamine thiolesters (SNAC) and tested in kinetic assays as substrates with an isolated DH domain. 3R-3-hydroxybutyryl SNAC 3R-16 was turned over by the enzyme, but its enantiomer was not. Of the four 2-methyl substrates only 2R,3R-2-methyl-3-hydroxybutyryl SNAC 2R,3R-8 was a substrate. Combined with stereochemical information from the isolated SQTKS enoyl reductase (ER) domain, our results provide a near complete stereochemical description of the first cycle of beta-modification reactions of a fungal highly reducing polyketide synthase (HR-PKS). The results emphasise the close relationship between fungal HR-PKS and vertebrate fatty acid synthases (vFAS).

Total Synthesis and Configurational Assignment of AscospiroketalA

Chang, Stanley,Hur, Soo,Britton, Robert

supporting information, p. 16646 - 16653 (2015/11/09)

The total synthesis of the marine fungus-derived natural product ascospiroketal is described. This concise synthesis relies on a unique AgI-promoted tandem cascade cyclization that provides direct access to the correctly configured tricyclic core of the natural product from a linear precursor. The synthesis of candidate stereostructures of ascospiroketalA allowed for the confident assignment of both the relative and absolute stereochemistry of this unusual octaketide.

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead

Du,Matsushima,Spyvee,Goto,Shirota,Gusovsky,Chiba,Kotake,Yoneda,Eguchi,DiPietro,Harmange,Gilbert,Li,Davis,Jiang,Zhang,Pelletier,Wong,Sakurai,Yang,Ito-Igarashi,Kimura,Kuboi,Mizui,Tanaka,Ikemori-Kawada,Kawakami,Inoue,Kawai,Kishi,Wang

supporting information; scheme or table, p. 6196 - 6199 (2010/06/19)

With bioactivity-guided phenotype screenings, a potent anti-inflammatory compound f152A1 has been isolated, characterized and identified as the known natural product LL-Z1640-2. Metabolic instability precluded its use for the study on animal disease model

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