155899-34-6

Basic information

• Product Name: 2(R)-Propyl-4-hexynoic acid
• Synonyms: ABS-103R; R-ABS-103; R-103
• CAS NO: 155899-34-6
• Molecular Formula: C₉H₁₄O₂
• Molecular Weight: 154.21073
• Mol File: 155899-34-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(R)-Propyl-4-hexynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2(R)-Propyl-4-hexynoic acid(155899-34-6)
• EPA Substance Registry System: 2(R)-Propyl-4-hexynoic acid(155899-34-6)

Safety Data

• Hazardous Substances Data: 155899-34-6(Hazardous Substances Data)

Usage

General Description

2(R)-Propyl-4-hexynoic acid is a chemical compound with the molecular formula C9H16O2. It is a carboxylic acid with a propyl and a hexynoic group attached to the carbon atom. 2(R)-Propyl-4-hexynoic acid is commonly used in the pharmaceutical industry as a key intermediate in the synthesis of various drugs. It is also used in the production of flavors and fragrances, as well as in the synthesis of organic compounds. The chemical properties of 2(R)-Propyl-4-hexynoic acid make it a versatile compound with a range of potential applications in various industries.

Upstream product

• 2163-48-6 diethyl propylmalonate 
• 3355-28-0 1-Bromo-2-butyne 

Relevant articles and documents

Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.

Twelve racemic analogues of the antiepileptic drug valproic acid (VPA) were tested and compared with VPA for anticonvulsant activity by the subcutaneous pentylenetetrazol (PTZ) seizure threshold test and for neurotoxicity by the rotorod test. Four compounds produced maximal anticonvulsant activity (100% protection) in equimolar doses (1.5 mmol/kg) to VPA and two compounds showed a similar effect with lower doses (1.0 mmol/kg). Four compounds produced lower activity (38-80% protection), and two compounds showed no anticonvulsant activity at the dose used (1.5 mmol/kg). Two of the 12 compounds, (+/-)-2-n-propyl-4-hexynoic acid (11) and (+/-)-4-methyl-2-n-propyl-4-pentenoic acid (12), showed no sedation at doses that produced the maximum anticonvulsant effect. For the first time we succeeded to develop two compounds with higher protective index and safety ratios than VPA. Compound 11 had a longer duration of action and higher protective index but a lower safety ratio than 12. Comparisons of the anticonvulsant and minimal neurotoxic effects of these compounds with their calculated lipophilicity (C log P) revealed that compounds with the desired high anticonvulsant activity and minimal neurotoxicity showed C log P values between 1.84 and 2.64 and had nine carbon atoms (in contrast to eight carbon atoms for VPA).