1559-88-2

Basic information

• Product Name: 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE
• Synonyms: BROMO-2,3,5,6-TETRAFLUOROBENZENE;2,3,5,6-TETRAFLUOROBROMO BENZENE;1-BROMO-2,3,5,6-TETRAFLUOROBENZENE;3-BROMO-1,2,4,5-TETRAFLUOROBENZENE;1-Bromo-2,3,5,6-tetrafluorbenzene;Benzene, 3-bromo-1,2,4,5-tetrafluoro-;1-Bromo-2,3,5,6-tetrafluorobenzene 99%;1-Bromo-2,3,5,6-tetrafluorobenzene99%
• CAS NO: 1559-88-2
• Molecular Formula: C₆HBrF₄
• Molecular Weight: 228.97
• EINECS: 216-327-9
• Product Categories: Benzene series;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 1559-88-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 143-143.5 °C(lit.)
• Flash Point: 129 °F
• Appearance: clear colorless liquid
• Density: 1.883 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.136mmHg at 25°C
• Refractive Index: n20/D 1.469(lit.)
• Storage Temp.: Flammables area
• Water Solubility: Not miscible or difficult to mix in water.
• CAS DataBase Reference: 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE(1559-88-2)
• EPA Substance Registry System: 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE(1559-88-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 10-36/37/38-22
• Safety Statements: 16-26-36/37/39-37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 1559-88-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

1-Bromo-2,3,5,6-tetrafluorobenzene is used to produce 1,2,4,5-tetrafluoro-3-hept-1-ynyl-benzene. It is also used as a pharmaceutical intermediate.

InChI:InChI=1/C6H3ClFI/c7-5-3-4(9)1-2-6(5)8/h1-3H

Upstream product

• 327-54-8 1,2,4,5-Tetrafluorobenzene 
• 2797-79-7 (4-bromo-2,3,5,6-tetrafluorophenyl)hydrazine 
• 769-40-4 2,3,5,6-tetrafluorothiophenol 
• 652-18-6 2,3,5,6-tetrafluorobenzoic acid 
• 344-03-6 1,4-dibromotetrafluorobenzene 
• 139-02-6 sodium phenoxide 
• 2062-98-8 perfluoro(2-propoxypropionyl) fluoride 
• 31103-33-0 4-bromotetrafluorophenylmagnesium bromide 
• 344-04-7 bromopentafluorobenzene 

Downstream Products

• 17823-37-9 1-bromo-2,3,5,6-tetrafluoro-4-nitrobenzene 
• 784-36-1 1-phenylthio-2,3,5,6-tetrafluorobenzene 
• 344-03-6 1,4-dibromotetrafluorobenzene 
• 63108-00-9 1-bromo-2,3,5,6-tetrafluoro-4-iodobenzene 
• 327-54-8 1,2,4,5-Tetrafluorobenzene 
• 20083-07-2 1-trimethylsilyl-2,3,5,6-tetrafluorobenzene 
• 137812-30-7 1-bromo-4-(trimethylsilyl)bromotetrafluorobenzene 
• 63107-92-6 2,3,5,6,2',3',5',6',2'',3'',5'',6'',2''',3''',5''',6'''-hexadecafluoro-<1,1';4',1'';4'',1'''>-quaterphenyl 
• 1835-58-1 4-bromotetrafluorophenyl(pentafluorophenyl)sulfane 
• 52331-31-4 bis(4-bromotetrafluorophenyl)sulfane 
• 23653-74-9 trimethyl(2,3,5,6-tetrafluorophenyl)tin 
• 1094249-93-0 (Et₂O)B(p-C₆F₄H)3 
• 1219809-82-1 (E)-1-bromo-2,3,5,6-tetrafluoro-4-styrylbenzene 
• 1219809-81-0 (E)-tert-butyl 3-(4-bromo-2,3,5,6-tetrafluorophenyl)acrylate 

Relevant articles and documents

Copper-catalyzed hydrodefluorination of fluoroarenes by copper hydride intermediates

Breaking bad: Efficient copper-catalyzed C-F bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in ?).

Reactions of dibromotetrafluorobenzene derivatives with sodium phenoxide salts. Competing hydrodebromination and SNAr processes

1,2- and 1,3-dibromotetrafluorobenzene react with sodium phenoxide derivatives at sites para to ring bromine because these positions are activated by fluorine atoms ortho and meta to the site of nucleophilic substitution. Fluorine para to the site of nucl