1559057-74-7Relevant articles and documents
PROCESS FOR THE PREPARATION OF TAFLUPROST AND INTERMEDIATES THEREOF
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Paragraph 0065, (2014/03/21)
The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.