155928-39-5

Basic information

• Product Name: 4-Amino-5-iodo-2-methoxybenzenecarboxylic acid
• Synonyms: 4-Amino-5-iodo-2-methoxybenzenecarboxylic acid;4-Amino-5-iodo-2-methoxybenzoic acid 95+%;4-Carboxy-6-iodo-3-methoxyaniline, 5-Amino-2-carboxy-4-iodoanisole
• CAS NO: 155928-39-5
• Molecular Formula: C₈H₈INO₃
• Molecular Weight: 293
• Mol File: 155928-39-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Air Sensitive
• CAS DataBase Reference: 4-Amino-5-iodo-2-methoxybenzenecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-5-iodo-2-methoxybenzenecarboxylic acid(155928-39-5)
• EPA Substance Registry System: 4-Amino-5-iodo-2-methoxybenzenecarboxylic acid(155928-39-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 155928-39-5(Hazardous Substances Data)

Usage

Uses

4-Amino-5-iodo-2-methoxybenzoic Acid is a useful reagent in preparation of N-(1,2,3,4-tetrahydroisoquinolinyl)benzamides as anticonvulsants.

Upstream product

• 516-12-1 N-iodo-succinimide 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 137832-56-5 methyl 4-amino-5-iodo-2-methoxybenzoate 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 201214-53-1 methyl 4-acetamido-5-iodo-2-methoxybenzoate 

Downstream Products

• 176849-94-8 4-acetamido-5-iodo-2-methoxybenzoic acid 
• 947263-60-7 4-acetamido-N-(4-(N-tert-butoxycarbonyl-N-butylamino)butyl)-5-iodo-2-methoxybenzamide 

Relevant articles and documents

Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma

The imaging potential of a series of [123I]benzamides was studied in mice bearing B16F0 melanoma tumors. Compound [123I]25 exhibited tumor uptake >8 %ID/g at 1 h, while that of [123I]14d and [123I]25 reached a maximum of 9-12 %ID/g at 6 h. Standardized uptake values of [123I]14d were higher than 100 between 24 and 72 h after injection. In haloperidol treated animals, the tumor uptake of [ 123I]14d was not significantly different to controls, while significant reduction of [123I]25 uptake was observed, supporting that [123I]14d uptake relates to melanin interaction, whereas part of the mechanism of [123I]25 uptake is related to its σ1-receptor affinity. Benzamides 14d and 25, which display rapid and high tumor uptake, appear to be promising imaging agents for melanoma detection, while 14d, which displays a long lasting and high melanoma/nontarget ratio, is more suitable for evaluation as a potential radiotherapeutic.

4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamides for treating smooth muscle contraction disorders

Piperidinyl substituted benzamides of formula STR1 the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R1 is hydrogen or halo; R2 is halo; R3 is hydrogen or halo; Rsup