155968-67-5Relevant academic research and scientific papers
Oxidation of Some Conjugated Diene Steroids by Hydrogen Peroxide Catalyzed by Methyltrioxorhenium
Lasalvia, Maria,Musumeci, Domenica,Piccialli, Vincenzo,Sica, Donato
, p. 2988 - 2995 (2007/10/03)
The oxidation of some conjugated diene steroids, namely Δ4,6-, Δ5, 7-, Δ7,9(11)- and Δ7,14- steroids, with hydrogen peroxide in the presence of catalytic amounts of methyltrioxorhenium (MTO) at room temperature
Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
-
, (2008/06/13)
Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) STR1 wherein R is a C-17 side chain, R1 is --OH, =O, or the like, and X and Y are N, N→O, CH, C--OH, C--OCH3 or C--Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.
