15598-33-1

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-4,6-DICHLORO-5-FLUOROPYRIMIDINE is used as an intermediate in the synthesis of various pharmaceuticals for its important biological activities. It serves as a key component in the creation of drugs targeting specific diseases and conditions, contributing to the development of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2-AMINO-4,6-DICHLORO-5-FLUOROPYRIMIDINE is employed as an intermediate in the synthesis of agrochemicals. Its incorporation into these products aids in enhancing crop protection and management, supporting agricultural productivity and sustainability.
Used as a Building Block in Chemical Synthesis:
2-AMINO-4,6-DICHLORO-5-FLUOROPYRIMIDINE is utilized as a versatile building block in the synthesis of a wide range of chemical compounds. Its unique structure and functional groups make it a valuable component in the creation of various chemical entities for diverse applications across different industries.

InChI:InChI=1S/C4H2Cl2FN3/c5-2-1(7)3(6)10-4(8)9-2/h(H2,8,9,10)

Upstream product

• 109-06-8 α-picoline 
• 669-96-5 2-amino-5-fluoro-4,6-dihydroxypyrimidine 

Relevant academic research and scientific papers

Industrial production method of 4,6-dichloro-5-fluoro-2-aminopyrimidine

The invention discloses an industrial production method of 4,6-dichloro-5-fluoro-2-aminopyrimidine, relating to the technical field of the industrial production of 4,6-dichloro-5-fluoro-2-aminopyrimidine. The industrial production method comprises the following steps: with 4,6-dihydroxy-5-fluoro-2-aminopyrimidine as the raw material, reacting with DMF and phosphorus oxychloride to obtain a chlorination product intermediate, adding a certain amount of water to generate quenching reaction, and directly heating for hydrolysis so as to generate a target product, wherein the intermediate is not separated; and removing an acidic reaction mother solution through centrifugation, carrying out drip washing on a filter cake by virtue of dilute ammonia water, and drying, so as to obtain the finished product, namely 4,6-dichloro-5-fluoro-2-aminopyrimidine. According to the method, the product yield is more than 85%, the product content is more than 98%, the water content is less than 0.5%, and theproduct is good in color. The acidic reaction solution does not need to be neutralized by virtue of a large amount of alkali in the production process, the production process is an environment-friendly production process, the yield is high, the production cost is lowered, the product impurity is high, and the later-period application is promoted.

5-fluoro-2,4,6-pyrimidinetriamine compounds

A 5-fluoro-minoxidil compound and compositions are disclosed which are useful in the treatment of hair growth and cardiovascular disorders. The 5-fluoro-minoxidil compounds have been shown to have increased transdermal transport than minoxidil and therefore can be used in decreased amounts to achieve the same pharmacological efficacy of minoxidil.