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Usage

Uses

Used in Pharmaceutical Industry:
3-Ethyl-1-adamantanol serves as a crucial building block in the organic synthesis of various pharmaceuticals. Its adamantane backbone and ethyl group attachment contribute to the development of novel drug molecules with potential therapeutic applications.
Used in Materials Science:
In the realm of materials science, 3-Ethyl-1-adamantanol is utilized for its structural and chemical properties to create advanced materials with specific characteristics, such as stability and reactivity, that are desirable for various applications.
Used in Chemical Research:
3-Ethyl-1-adamantanol's unique molecular structure and reactivity make it an interesting subject for chemical research. It can be employed to study reaction mechanisms, explore new synthetic pathways, and develop innovative chemical processes.
Overall, 3-Ethyl-1-adamantanol's versatility in different fields underscores its importance as a chemical intermediate with broad applications in medicine, materials science, and chemical research.

Upstream product

• 770-69-4 1-ethyladamantane 
• 878-61-5 1-Bromo-3-ethyladamantane 
• 37845-05-9 3-ethyladamantane-1-carboxylic acid 
• 101821-76-5 3-ethyladamant-1-yl nitrate 
• 70298-17-8 acetate de ethyl-3 adamantyl-1 
• 108-24-7 acetic anhydride 

Downstream Products

• 41100-45-2 1-amino-3-ethyl-adamantane 
• 101821-81-2 3-ethyl-1-adamantylacetic acid 

Relevant academic research and scientific papers

Preparation process of amantadine nitrate derivative

The invention discloses a preparation process of an amantadine nitrate derivative, and the amantadine nitrate derivative is prepared from substituted or unsubstituted adamantane as a raw material by the following steps: (1) synthesizing of adamantanol; (2) carboxylation of the adamantanol; (3) amidation of adamantane acid; (4) reduction; (5) hydrolysis of acylamino adamantanol and boc protection of amino; (6) crystallization of Boc-protected amantadine alcohol; (7) nitric acid esterification of Boc-protected amantadine alcohol; (8) refining of a nitric acid esterification product; (9) amino deprotection and salt formation; and (10) refinement of amantadine nitrate. The amantadine amine nitrate derivative is as shown in the specification, wherein R1 and R2 are same or different, and are respectively hydrogen, a linear or branched alkyl group, a substituted or unsubstituted aryl group and a hetero aryl group. The preparation process is efficient, economic, green, safe and reliable and issuitable for industrial production.

Liquid-phase oxidation of alkanes with molecular oxygen catalyzed by high valent iron-based perovskite

Hexagonal BaFeO3-δ containing high valent iron species acted as an efficient heterogeneous catalyst for the aerobic oxidation of alkanes without the need for additives. The activity of BaFeO3-δ was much higher than that of typical Fe3+/Fe2+-containing iron oxide-based catalysts, and the recovered catalyst could be reused without significant loss of catalytic performance.

Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases

A series of memantine nitrate derivatives, as dual functional compounds with neuroprotective and vasodilatory activity for neurodegenerative diseases, was designed and synthesized. These compounds combined the memantine skeleton and a nitrate moiety, and thus inhibited the N-methyl-d-aspartic acid receptor and released NO in the central nervous system. The biological evaluation results revealed that the new memantine nitrates were effective in protecting neurons against glutamate-induced injury in vitro. Moreover, memantine nitrates dilated aortic rings against phenylephrine-induced contraction. The structure-activity relationships of neuroprotection and vasodilation were both analyzed. In further studies, compound MN-05 significantly protected cortical neurons by inhibiting Ca2+ influx, reducing free radical production and maintaining the mitochondrial membrane potential. Further research on MN-05 is warranted.

One-pot synthesis of cage alcohols

An efficient one-pot procedure has been developed for the synthesis of cage alcohols with hydroxy groups in the bridgehead positions. The procedure includes initial nitroxylation with nitric acid or a mixture of nitric acid with acetic acid and subsequent hydrolysis in the presence of urea.

Synthesis of hydroxy derivatives from adamantanecarboxylic acids in the system MnO2–H2SO4

A convenient procedure has been developed for the synthesis of mono- and dihydric cage alcohols from adamantanecarboxylic acids and their esters using the MnO2–H2SO4system. The reaction at elevated temperature involved both decarboxylation and decarbonylation of the initial acid or ester.

Formation of adamantan-1-ols by the reactions of adamantanes with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) in trifluoromethanesulfonic acid

Adamantanes were treated with DDQ in trifluoromethanesulfonic acid followed by hydrolysis to give adamantan-1-ols in good yields.

Synthese en serie adamantane : preparation d'adamantanes trisubstitues-1,2,3 et -1,2,5 et de protoadamantanones -4 substituees en position -6 ou -8

A regio and diastereospecific synthetic approach to 1,3-dialkyl (and 1,3-diphenyl) adamantanes bearing a functional group in position-2 (7) and to 1,5-dialkyl (and 1,5-diphenyl) 2-adamantanols (syn 8) is described.This has been accomplished through an addition-isomerisation process on two new classes of 4-protoadamantanones bearing a substituent in position 8 or 6 (3 and 4).These have been prepared via an intramolecular base catalysed cyclisation of iodoketones (11), obtained by thermolysis of hypo-iodites (10).