15598-88-6Relevant academic research and scientific papers
Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases
Liu, Zheng,Yang, Si,Jin, Xiaoyong,Zhang, Gaoxiao,Guo, Baojian,Chen, Haiyun,Yu, Pei,Sun, Yewei,Zhang, Zaijun,Wang, Yuqiang
, p. 135 - 147 (2017/02/05)
A series of memantine nitrate derivatives, as dual functional compounds with neuroprotective and vasodilatory activity for neurodegenerative diseases, was designed and synthesized. These compounds combined the memantine skeleton and a nitrate moiety, and thus inhibited the N-methyl-d-aspartic acid receptor and released NO in the central nervous system. The biological evaluation results revealed that the new memantine nitrates were effective in protecting neurons against glutamate-induced injury in vitro. Moreover, memantine nitrates dilated aortic rings against phenylephrine-induced contraction. The structure-activity relationships of neuroprotection and vasodilation were both analyzed. In further studies, compound MN-05 significantly protected cortical neurons by inhibiting Ca2+ influx, reducing free radical production and maintaining the mitochondrial membrane potential. Further research on MN-05 is warranted.
TRIFLUOROACETIC ANHYDRIDE AS A MEDIUM FOR ORGANIC REACTIONS. FUNCTIONAL SUBSTITUTION OF ADAMANTANE AND ITS DERIVATIVES
Kovalev, V. V.,Fedorova, O. A.,Shokova, E. A.
, p. 1672 - 1675 (2007/10/02)
The role of trifluoroacetic anhydride during the oxidation of adamantane and its derivatives with sulfuric acid was studied. 1-Adamantanol, 1-(4-methyl-3-nitrophenyl)-3-adamantanol.The latter was used without isolation from the reaction mixture for the production of 1-adamantanecarboxylic acid, N-(1-adamantyl)acetamide, 1-(1-adamantyl)butan-1-ol, 1-(4-methylphenyl)adamantane, 4-(1-adamantyl)phenoxyacetic acid, 4-(1-adamantyl)acetanilide, and 4-(1-adamantyl)bromobenzene.
