155988-37-7Relevant articles and documents
Sequential Formal [4+1]-Cycloaddition, C?H Functionalization and Suzuki–Miyaura Cross-Coupling for the Synthesis of Trisubstituted Isoxazolines
Ioffe, Sema L.,Sukhorukov, Alexey Yu.,Tabolin, Andrey A.,Ushakov, Pavel Yu.
, p. 2680 - 2693 (2021)
Suzuki–Miyaura cross-coupling reaction of 3-bromomethyl isoxazolines with arylboronic acids was suggested as final C?C bond forming step in convenient diastereoselective route to trisubstituted isoxazolines. The required bromides were readily available fr
Catalytic enantioselective epoxidation of nitroalkenes
Vidal-Albalat,?widerek,Izquierdo,Rodríguez,Moliner,González
supporting information, p. 10060 - 10063 (2016/08/15)
Nitroepoxides are potentially exploitable as synthons with vicinal electrophilic centers. Nevertheless, although advances have been made in the field, enantioselective epoxidation of nitroalkenes is still a challenging process. Herein we show a convenient procedure for the preparation of optically active nitroepoxides in high enantiomeric excess and high chemical yield. The kinetic data of the best catalyst have been examined using computational methods based on DFT calculations. Interestingly, the results demonstrate that the enantioselectivity of the epoxidation of nitroalkenes by this kind of catalyst is not only kinetically but also thermodynamically controlled.
