155990-11-7

Basic information

• Product Name: N-[1-[2-(Diethylamino)ethylamino]-10-oxo-10H-dibenzo[b,e]thiopyran-4-ylmethyl]carbamic acid methyl ester
• Synonyms: SW-68210
• CAS NO: 155990-11-7
• Molecular Formula: C₂₂H₂₇N₃O₃S
• Molecular Weight: 413.54279
• Mol File: 155990-11-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[1-[2-(Diethylamino)ethylamino]-10-oxo-10H-dibenzo[b,e]thiopyran-4-ylmethyl]carbamic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-[2-(Diethylamino)ethylamino]-10-oxo-10H-dibenzo[b,e]thiopyran-4-ylmethyl]carbamic acid methyl ester(155990-11-7)
• EPA Substance Registry System: N-[1-[2-(Diethylamino)ethylamino]-10-oxo-10H-dibenzo[b,e]thiopyran-4-ylmethyl]carbamic acid methyl ester(155990-11-7)

Safety Data

• Hazardous Substances Data: 155990-11-7(Hazardous Substances Data)

Upstream product

• 75-31-0 isopropylamine 
• 79-22-1 methyl chloroformate 
• 146537-05-5 4-(aminomethyl)-1-[[2-(diethylamino)ethyl]amino]-thioxanthen-9-one 
• 146537-03-3 N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxothioxanthen-4-yl]methyl]formamide 
• 3613-13-6 1-[[2-(diethylamino)-ethyl]amino]-9-oxo-thioxanthen-4-carboxaldehyde 

Relevant articles and documents

Thioxanthenone antitumor agents

Compounds having anti-tumour activity are disclosed having the formulawherein: (1) n is 2 or 3;R1 and R2 are independently lower-alkyl;Q is a residue chosen from the group consisting ofCH2NHR3, CH2N(R4)SO2R7, CH2NHCHO, CH=N-Ar,C(O)NR5R6, CH2N(R4)C(O)R7, CH2N(C2H5)CHO,CH2N(R4)P(O)(O-lower-alkyl)2, CH2N=CH-N(R9)(R10),CH2N(R4)C(O)CF3 and CH2N(R4)C(O)OR7;R3 is hydrogen or lower-alkyl;R4 is hydrogen, lower-alkyl or Ar;R5 is hydrogen, lower-alkyl or Ar;R6 is hydrogen or lower-alkyl;R7 is lower-alkyl, or Ar;R8 is hydroxy;Ar is phenyl or phenyl substituted with methyl, methoxy, hydroxy, halogen or nitro; andR9 and R10 are independently lower-alkyl; or(2) Q is a residue chosen from the group consisting of CH2N(R4)SO2R7, CH=N-Ar, C(O)NR5R6, CH2N(R4)C(O)R7, CH2N(R4)P(O)(O-lower-alkyl)2, CH2N(R4)C(O)CF3 and CH2N(R4)C(O)OR7; R8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; Ar is phenyl substituted by hydroxy; and n, R1, R2, R4, R5, R6, and R7 are as defined hereinabove in part (1) with the proviso that one or more of R4, R5, or R7 is Ar; or(3) Q is a residue chosen from the group consisting of CH2N=CH-N(R9)(R10) and CH2N(R4)C(O)CF3 ; R8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; and n, R1, R2, R4, R7, Ar, R9 and R10 are as defined hereinabove in part (1), or a pharmaceutically acceptable acid-addition salt or solvate thereof . Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

Lyophilized thioxanthenone antitumor agents

Disclosed are reconstituted lyophilized formulations for the treatment of mammalian tumors comprising a thioxanthenone antitumor agent in combination with mannitol or sucrose as a stabilizer in a lactate buffer.