1560-52-7Relevant academic research and scientific papers
Pharmacokinetics, metabolism and toxicity of the plant-derived photoxin α-teuthienyl
Marles,Durst,Kobaisy,Soucy-Breau,Abou-Zaid,Arnason,Kacew,Kanjanapothi,Rujianawate,Meckes,Lozoya
, p. 164 - 168 (1995)
The plant-derived insecticide, a-terthienyl was prepared by synthesis as 3',4'-di[14C]-α-terthienyl for pharmacokinetic and metabolism studies. When administered orally to rats at a single dose of 50 mg/kg, excretion of the labelled material wa
An efficient synthesis of carbon-14 labelled vigabatrin
Gill
, p. 425 - 430 (1995)
Vigabatrin-[6-14C] ((R,S)-4-amino-5-hexenoic-[6-14C] acid) was synthesized by employing Wittig condensation of 1-(1-butenyI)-2-oxo-5-pyrrolidinecarboxaldehyde with methyl-[14C]-triphenylphosphonium iodide as the key step.
Photochemical Synthesis of Carbon-14 Labelled Dibenzanthracene
Platt, Karl L.,Setiabudi, Frans
, p. 2005 - 2010 (2007/10/02)
Carrier-free dibenzanthracene (DBA,12*) has been prepared for the first time using methyl iodide as the source of the label.The key step in this radiosynthesis consisted of the regiospecific photocyclization of 2',5'-divinyl-1,1':4',1''-terphenyl 10* to 5,6,12,13-tetrahydro-DBA 11* followed by dehydrogenation to 12* with DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone).Divinylterphenyl 10* was obtained from 2',5'-bis(bromomethyl)-1,1':4',1''-terphenyl 3 via the diformyl derivative 9 and its Wittig olefination with the triphenylphosphonium salt of14CH3I.Thus 12* was synthesized with a radiochemical purity exceeding 99percent.The chemical yield amounted to 58percent from 9 in the case of 12* with a specific activity of 391 MBq mmol-1 and to 12percent in the case of carrier-free 12* with a specific activity of 4.14 GBq mmol-1.Wide applicability of this radiosynthetic approach to the preparation of many other carbon-14 labelled polycyclic aromatic hydrocarbons can be envisaged.
