156002-95-8Relevant academic research and scientific papers
Effect on α-glucosidase inhibition and antioxidant activities of butyrolactone derivatives from Aspergillus terreus MC751
Dewi, Rizna Triana,Tachibana, Sanro,Darmawan, Ahmad
, p. 454 - 460 (2014)
Butyrolactone I and II from Aspergillus terreus MC751 as well as three synthetic butyrolactone I derivatives were assessed for α-glucosidase inhibitory and antioxidant activities. Butyrolactone I (1), which has a prenyl side chain and an alpha hydroxy-lactone group, was the most potent α-glucosidase inhibitor and also had antioxidant activities with IC 50 values of 52.17 ± 5.68 and 51.39 ± 3.68 μM, respectively. In contrast, butyrolactone II (2) lacking a prenyl side chain was the most potent antioxidant with an IC50 of 17.64 ± 6.41 μM, but was less active against α-glucosidase. Acetylation of all hydroxyl groups of butyrolactone I significantly decreased both the α-glucosidase inhibitory and antioxidant activity. The prenyl and alpha hydroxy-lactone groups seem to have a synergic effect on the inhibitory activity but not antioxidant activity. This is the first structure-activity relationship report on the α-glucosidase inhibition and antioxidant activity by butyrolactone derivatives.
