15601-64-6

Upstream product

• 53341-66-5 ethyl 3-oxo-3-(phenylamino)propionate 
• 102626-05-1 ethyl 3-amino-2-phenylaminocarbonyl-2-butenoate 
• 62-53-3 aniline 

Downstream Products

• 134715-30-3 4-<3'-(1'-anilinomalonyl-5'-phenyl)pyrazolinyl>morpholine 
• 75205-75-3 1-anilinomalonyl-3-methyl-4-(4'-nitrobenzeneazo)-5-pyrazolone 
• 75205-51-5 1-anilinomalonyl-3-methyl-4-(4'-methylbenzeneazo)-5-pyrazolone 
• 135033-83-9 3-[4-(2-Fluoro-phenylazo)-3,5-dimethyl-pyrazol-1-yl]-3-oxo-N-phenyl-propionamide 
• 135033-78-2 1-(anilinomalonyl)-3,5-dimethyl-4-(o-chlorophenylazo)pyrazole 
• 134715-29-0 10-<3'-(1'-anilinomalonyl-5'-phenyl)pyrazolinyl>phenothiazine 
• 139032-65-8 1-(anilinomalonyl)-3-(N-o-methylanilino-N-β-cyanoethylamino)-5-phenylpyrazoline 
• 142428-34-0 1-anilinomalonyl-3,5-diphenyl-4-(2'-methyl)phenylazopyrazole 
• 142428-74-8 3-[4-(2,5-Dichloro-phenylazo)-3,5-dimethyl-pyrazol-1-yl]-3-oxo-N-phenyl-propionamide 
• 142428-64-6 3-[4-(4-Methoxy-phenylazo)-3,5-diphenyl-pyrazol-1-yl]-3-oxo-N-phenyl-propionamide 
• 142428-54-4 3-[4-(2-Methoxy-phenylazo)-3,5-diphenyl-pyrazol-1-yl]-3-oxo-N-phenyl-propionamide 
• 139951-85-2 1-anilinomalonyl-3-phenyl-4-(2-carboxyphenylazo)-5-pyrazolone 
• 881012-24-4 2-[1-[5-(3-Chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-N-phenyl-acetamide 
• 881012-28-8 2-[1-[5-(4-Chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-N-phenyl-acetamide 

Relevant academic research and scientific papers

Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors

HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.

Efficient synthesis of 4-ethoxycarbonyl pyrazolin-5-one derivatives

Concise and efficient methods for the preparation of 3-substituted 4-ethoxycarbonylpyrazolin-5-ones are described. The synthetic strategies involve carbon-acylation in the presence of base, followed by ring cyclization with hydrazine or hydrazine monohydrochloride.