156017-66-2Relevant academic research and scientific papers
A transition-metal mediated regioselective synthesis of phenyl quinones via sequential benzannulation and cross coupling reactions
Kin Shing Chan,Chi Ching Mak
, p. 2003 - 2016 (2007/10/02)
A synthetic route for the regioselective synthesis of polysubstituted quinones by the benzannulation and subsequent cross coupling reactions has been developed. Alkenyl chromium carbene complexes undergo regioselective benzannulation with 2-(trimethylsilyl)-1-phenylethyne with oxidative workup to yield silyl quinones which upon iodination with ICI produce iodoquinones. Subsequent Stille's and Suzuki's cross coupling reactions of these iodoquinones yield polysubstituted quinones.
