156040-03-8Relevant articles and documents
Selective N-Demethylation of galanthamine to norgalanthamine via a non classical Polonovski reaction
Mary, Aude,Renko, Dolor Zafiarisoa,Guillou, Catherine,Thal, Claude
, p. 5151 - 5152 (1997)
The previously unknown N-demethylation of galanthamine 1 to norgalanthamine 3 was selectively accomplished by a non classical Polonovski reaction using iron salts. This transformation constitutes the first example of the application of the Polonovski reaction to an N-oxide of a seven membered cyclic amine. Norgalanthamine is a valuable intermediate in new Solanthamine derivatives synthesis.
Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity
Atanasova, Mariyana,Stavrakov, Georgi,Philipova, Irena,Zheleva, Dimitrina,Yordanov, Nikola,Doytchinova, Irini
, p. 5382 - 5389 (2015)
The inhibitors of acetylcholinesterase are the main therapy against Alzheimer's disease. Among them, galantamine is the best tolerated and the most prescribed drug. In the present study, 41 galantamine derivatives with known acetylcholinesterase inhibitor
Galantamine derivatives as acetylcholinesterase inhibitors: Docking, design, synthesis, and inhibitory activity
Doytchinova, Irini,Atanasova, Mariyana,Stavrakov, Georgi,Philipova, Irena,Zheleva-Dimitrova, Dimitrina
, p. 163 - 176 (2017/10/25)
Galantamine (GAL) is a well-known acetylcholinesterase (AChE) inhibitor, and it is widely used for treatment of Alzheimer’s disease. GAL fits well in the catalytic site of AChE, but it is too short to block the peripheral anionic site (PAS) of the enzyme,