156042-32-9Relevant articles and documents
PMS synthesis method
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, (2021/02/10)
The invention discloses a PMS synthesis method, and belongs to the technical field of organic synthesis. The method comprises the following steps: reacting L-serine methyl ester hydrochloride with palmitoyl chloride to obtain N-palmitoyl-L-serine methyl ester; carrying out benzyl protection on the N-palmitoyl-L-serine methyl ester, and hydrolyzing the methyl ester to obtain N-palmitoyl-O-benzyl-L-serine; esterifying the N-palmitoyl-O-benzyl-L-serine and tetradecyl alcohol to obtain N-palmitoyl-O-benzyl-L-serine tetradecyl ester; and finally, debenzylating the N-palmitoyl-O-benzyl-L-serine tetradecyl ester to obtain the PMS. According to the invention, cheap L-serine methyl ester hydrochloride is used as a raw material, and benzyl is used for protecting hydroxyl, so that the side reaction of esterification with tetradecyl alcohol when the hydroxyl in a serine parent is not protected is effectively avoided, the reaction conversion rate is improved, the difficulty of separation and purification caused by byproducts is reduced, and the method can be effectively suitable for industrial mass production.