156044-28-9Relevant articles and documents
Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity
Eissa, Amal A.M.,Aljamal, Kholoud F.M.,Ibrahim, Hany S.,Abdelrasheed Allam, Heba
, (2021/09/06)
The present study describes the synthesis of three series of 4-substituted pyridopyrimidin derivatives 4a-h, 5a-d. 6a-d, starting from 2-amino-6-(4-methoxyphenyl)-4-(4-(substituted) phenyl)nicotinonitrile 2a-d via the reaction with N,N-dimethyl-N-' substi
One-pot synthesis of 2-amino-3-cyanopyridines and hexahydroquinolines using eggshell-based nano-magnetic solid acid catalyst via anomeric-based oxidation
Akbarpoor, Tahere,Khazaei, Ardeshir,Seyf, Jaber Yousefi,Sarmasti, Negin,Gilan, Maryam Mahmoudiani
, p. 1539 - 1554 (2019/12/11)
Abstract: In the present research, the eggshell as a hazardous waste by European Union regulations was converted to a valuable catalyst, namely nano-Fe3O4@(HSO4)2. The as-prepared catalyst, first, was characterized using different techniques, including Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Back-titration method confirmed the loading of a high surface density of acidic group, namely 8.8?mmol HSO4 per gram of the catalyst. The catalytic property of the as-prepared catalyst was examined in the synthesis of 2-amino-3-cyanopyridines via anomeric-based oxidation (ABO), and hexahydroquinolines derivatives. High yield, short reaction time, solvent-free condition, waste to wealth, and optimization with the design of experiment are the major advantages of the present work. Taken together, these results suggest the conversion of waste to wealth products around the world and usage in organic transformation. Graphic abstract: [Figure not available: see fulltext.].
The green synthesis of 2-amino-3-cyanopyridines using SrFe12O19 magnetic nanoparticles as efficient catalyst and their application in complexation with Hg2+ ions
kheilkordi, Zohreh,Mohammadi Ziarani, Ghodsi,Bahar, Shahriyar,Badiei, Alireza
, p. 365 - 372 (2019/01/28)
Abstract: In this paper, a family of 2-amino-4,6-diphenylnicotinonitriles are prepared from aromatic aldehydes, acetophenone derivatives, malononitrile, and ammonium acetate via one-pot reaction catalyzed by SrFe12O19 magnetic nanoparticles. SrFe12O19 was an efficient, green, and reusable nanomagnetic heterogeneous catalyst with the average particles’ size of 70?nm which can be recycled and readily and separated from the reaction mixture using an external magnet. Short reaction times and high yields of desired products are the main advantages of the presented procedure. Subsequently, the spectrophotometric method was used to investigation of the complexation process between 2-amino-4,6-diphenylnicotinonitrile as organo-ligand and several metal ions such as Ag+, Cd2+, Co2+, Cr3+, Cu2+, Fe3+, Hg2+, Mn2+, Ni2+, Pb2+, and Zn2+ in CH3CN solution at 25?°C. According to the obtained results, the absorption spectra of organo-ligand in the CH3CN solution only were changed by the addition of Hg2+ ions, which indicates the formation of one absorbing complex compound between organo-ligand and Hg2+ ions. The stoichiometry of the resulting complex was calculated from the computer fitting of the molar absorbance measurements in different mole ratios. Graphical abstract: [Figure not available: see fulltext.].
