156046-05-8 Usage
General Description
Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride is a chemical compound with a complex molecular structure. It is a salt form of the organic compound methyl (S)-4,4-difluoropyrrolidine-2-carboxylate, which is commonly used as a building block in the synthesis of pharmaceutical drugs. The hydrochloride form is often used in medicinal chemistry research and drug development due to its stability and ease of handling. Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride is of interest due to its potential pharmacological properties and may have applications in the development of new medications. It is important to handle and use this chemical with caution, following proper safety protocols and guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 156046-05-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,0,4 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 156046-05:
(8*1)+(7*5)+(6*6)+(5*0)+(4*4)+(3*6)+(2*0)+(1*5)=118
118 % 10 = 8
So 156046-05-8 is a valid CAS Registry Number.
156046-05-8Relevant articles and documents
Synthesis of (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives from (S)-aspartic acid
Burger, Klaus,Rudolph, Martin,Fehn, Susanna,Sewald, Norbert
, p. 87 - 90 (1994)
Syntheses for (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives are described starting from (S)-aspartic acid, using hexafluoroacetone as the protecting reagent and DAST as the fluorinating agent.
Origin of the stability conferred upon collagen by fluorination
Shoulders, Matthew D.,Kamer, Kimberli J.,Raines, Ronald T.
supporting information; experimental part, p. 3859 - 3862 (2010/03/03)
According to a prevailing theory, (2S,4R)-4-hydroxyproline (Hyp) residues stabilize the collagen triple helix via a stereoelectronic effect that preorganizes appropriate backbone torsion angles for triple-helix formation. This theory is consistent with th
