156073-28-8

Basic information

• Product Name: 3-BroMo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
• Synonyms: 3-BroMo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
• CAS NO: 156073-28-8
• Molecular Formula: C14H9BrClNO
• Molecular Weight: 322.58436
• Product Categories: Amines, Heterocycles, Metaboites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 156073-28-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, DCM
• CAS DataBase Reference: 3-BroMo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(156073-28-8)
• EPA Substance Registry System: 3-BroMo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(156073-28-8)

Safety Data

• Hazardous Substances Data: 156073-28-8(Hazardous Substances Data)

Usage

Description

3-Bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a chemical compound that serves as an intermediate in the synthesis of Loratadine (L469575) metabolites. It is characterized by its unique molecular structure, which includes a benzo[5,6]cyclohepta[1,2-b]pyridin-11-one core with a bromine atom at the 3-position and a chlorine atom at the 8-position. 3-BroMo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one plays a crucial role in the pharmaceutical industry due to its involvement in the production of Loratadine metabolites.

Uses

Used in Pharmaceutical Industry:
3-Bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is used as an intermediate in the synthesis of Loratadine metabolites for the development of antihistamine medications. Loratadine is a widely used antihistamine drug that helps alleviate symptoms of allergies, such as sneezing, itching, and runny nose. The compound's role in the synthesis process is essential for creating effective and safe medications to combat allergic reactions.

Upstream product

• 165740-12-5 ethyl 4-(3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate 

Downstream Products

• 165739-70-8 8-CHLORO-3-METHOXY-5,6-DIHYDRO-11H-BENZO[5,6]-CYCLOHEPTA[1,2-b]PYRIDIN-11-ONE 
• 205044-28-6 [(R)-2-(4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-oxo-1-tritylsulfanylmethyl-ethyl]-carbamic acid tert-butyl ester 
• 205044-74-2 {(R)-2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-1-tritylsulfanylmethyl-ethyl}-carbamic acid tert-butyl ester 
• 212496-54-3 {(R)-1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-ylmethyl]-2-tritylsulfanyl-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

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