156079-79-7Relevant academic research and scientific papers
Use of 'click chemistry' for the synthesis of tetrazole-containing analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid
Hung, Kuo-Yuan,Harris, Paul W. R.,Brimble, Margaret A.
, p. 1233 - 1236 (2009)
Tetrazole-containing analogues of glycyl-L-prolyl-L-glutamic acid (GPE) were prepared by coupling of Cbz-glycyl-L-proline with tetrazole-containing glutamic acids followed by hydrogenation of the resultant tripeptide. Synthesis of the tetrazole-containing glutamic acids involved 1,3-dipolar cycloaddition of sodium azide to nitrile derivatives of the corresponding glutamic acids. Georg Thieme Verlag Stuttgart.
