1560811-70-2Relevant academic research and scientific papers
Asymmetric allylation/pauson-khand reaction: A simple entry to polycyclic amines. Application to the synthesis of aminosteroid analogues
Fustero, Santos,Lazaro, Ruben,Aiguabella, Nuria,Riera, Antoni,Simon-Fuentes, Antonio,Barrio, Pablo
, p. 1224 - 1227 (2014)
Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
