156094-64-3

Basic information

• Product Name: Pyridine, 3-bromo-2-(bromomethyl)-6-methoxy-
• Synonyms: Pyridine, 3-bromo-2-(bromomethyl)-6-methoxy-
• CAS NO: 156094-64-3
• Molecular Formula: C7H7Br2NO
• Molecular Weight: 280.947
• Mol File: 156094-64-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-bromo-2-(bromomethyl)-6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-bromo-2-(bromomethyl)-6-methoxy-(156094-64-3)
• EPA Substance Registry System: Pyridine, 3-bromo-2-(bromomethyl)-6-methoxy-(156094-64-3)

Safety Data

• Hazardous Substances Data: 156094-64-3(Hazardous Substances Data)

Upstream product

• 1214332-49-6 methyl 3-bromo-6-methoxypyridine-2-carboxylate 
• 1214328-96-7 methyl 3-bromo-6-chloro-pyridine-2-carboxylate 
• 929000-66-8 3-bromo-6-chloropyridine-2-carboxylic acid 
• 3279-76-3 6-hydroxy-2-methylpyridine 
• 126717-59-7 3-bromo-6-methoxy-2-methylpyridine 
• 623942-84-7 2-(hydroxymethyl)-3-bromo-6-methoxypyridine 
• 63071-03-4 2-methoxy-6-methyl-pyridine 

Downstream Products

• 1391435-98-5 C₁₉H₂₇BrN₂O₄ 
• 1394002-81-3 C₁₉H₂₇BrN₂O₄ 
• 116-28-9 huperzine A 
• 103548-82-9 (4aR,5R,10bR)-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-prop[1]eno-1,7-phenanthrolin-8(7H)-one 
• 107965-41-3 (4aR,5S,10bR,12S)-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthrolin-8(7H)-one 
• 1391436-01-3 C₁₉H₂₅BrN₂O₄ 
• 1393110-75-2 C₁₉H₂₅BrN₂O₄ 
• 1379526-10-9 C₂₃H₂₇BrN₂O₂Si 
• 1379526-17-6 C₂₅H₃₀N₂OSi 
• 1379526-12-1 C₂₅H₃₀N₂OSi 
• 1379526-11-0 C₂₃H₂₆N₂O₂Si 
• 1393110-64-9 C₂₁H₃₁BrN₂O₄ 
• 1393110-66-1 C₂₁H₃₁BrN₂O₄ 
• 1393110-47-8 C₂₄H₃₃BrN₂O₆ 

Relevant articles and documents

Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis

Non-alcoholic fatty liver disease (NAFLD) is becoming the most predominant burden of chronic liver disease worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, can develop into cirrhosis and hepatocellular cancer. Unfortunately, current options for therapeutic treatment of NASH are very limited. Among multiple pathways in NASH, farnesoid X receptor (FXR), a nuclear bile acid receptor, is well-recognized as an important effective target. Here we report the synthesis and characterization of compound HEC96719 a novel tricyclic FXR agonist based on a prior high-affinity nonsteroidal molecule GW4064. HEC96719 exhibits excellent potency superior to GW4064 and obeticholic acid in in vitro and in vivo assays of FXR activation. It also shows higher FXR selectivity and more favorable tissue distribution dominantly in liver and intestine. Preclinical data on pharmacokinetic properties, efficacy, and safety profiles overall indicate that HEC96719 is a promising drug candidate for NASH treatment.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

A process for the synthesis of intermediates in the preparation method of the huperzine-a

The invention discloses a preparation method of an intermediate for synthesizing huperzine A. The preparation method comprises the following steps: substituting 3-bromine-6-methoxy-2-methyl pyridine taken as a raw material with N-bromosuccinimide so as to obtain a substitution product; carrying out a reaction on the substitution product and methyl acetoacetate and then carrying out ring closing reaction under the action of cuprous iodide so as to obtain 2-methoxy-6-hydroxy-7,8-dihydro-5-quinoline carboxylic methyl ester. According to the method provided by the invention, the synthesis reaction cost is low, so that the production cost is effectively lowered; the reaction conditions are moderate, so that the safety of operating personnel is ensured; a refining process is convenient and simple to operate; the intermediate obtained via the reaction is good in quality, high in yield and good in environmental friendliness.