156146-13-3

Basic information

• Product Name: N-but-1-yn-4-yl-N-phenylamine
• Synonyms: N-but-1-yn-4-yl-N-phenylamine
• CAS NO: 156146-13-3
• Molecular Weight: 145.204
• Mol File: 156146-13-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: N-but-1-yn-4-yl-N-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-but-1-yn-4-yl-N-phenylamine(156146-13-3)
• EPA Substance Registry System: N-but-1-yn-4-yl-N-phenylamine(156146-13-3)

Safety Data

• Hazardous Substances Data: 156146-13-3(Hazardous Substances Data)

Upstream product

• 62001-29-0 N-phenyl-1H-benzotriazolyl-1-methanamine 
• 106-96-7 propargyl bromide 
• 43001-25-8 4-iodobut-1-yne 
• 62-53-3 aniline 
• 38771-21-0 4-bromobut-1-yne 
• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 
• 100-62-9 N-methylenebenzenamine 
• 125464-61-1 propargyl aluminum sesquibromide 

Downstream Products

• 1128054-37-4 C₁₇H₁₇N 
• 54105-26-9 1-phenyl-2,3,3a,3b,4,5,6,11b-octahydro-1H-dipyrrolo<1,2-a:3',2'-c>quinoline 

Relevant articles and documents

The Diverse Reactivity of Homopropargylic Amines as “Masked” 1C Synthons for the Aza-Friedel–Crafts Alkylation of Indoles

A novel type of “masked” 1C synthon was developed through the hydroamination cyclization-protonation of homopropargylic amines to act as aza-Friedel–Crafts alkylation reagents to react with indoles. A variety of 3-(2-pyrrolidinyl)indoles were generated in good to high yields. More significantly, some of the corresponding products display potential bioactivity against chlamydial infection, wherein they specifically target the mid-stage of the chlamydial life cycle by interfering with RB replication.

Metal-free, redox-neutral, site-selective access to heteroarylamine via direct radical?radical cross-coupling powered by visible light photocatalysis

Transition-metal-catalyzed C?N bond-forming reactions have emerged as fundamental and powerful tools to construct arylamines, a common structure found in drug agents, natural products, and fine chemicals. Reported herein is an alternative access to heteroarylamine via radical?radical cross-coupling pathway, powered by visible light catalysis without any aid of external oxidant and reductant. Only by visible light irradiation of a photocatalyst, such as a metal-free photocatalyst, does the cascade single-electron transfer event for amines and heteroaryl nitriles occur, demonstrated by steady-state and transient spectroscopic studies, resulting in an amine radical cation and aryl radical anion in situ for C?N bond formation. The metal-free and redox economic nature, high efficiency, and site-selectivity of C?N cross-coupling of a range of available amines, hydroxylamines, and hydrazines with heteroaryl nitriles make this protocol promising in both academic and industrial settings.

HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.