156149-37-0

Upstream product

• 41994-91-6 4-chloro-2-nitrobenzoic amide 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 34662-32-3 4-chloro-2-nitrobenzonitrile 
• 38487-86-4 2-amino-4-chlorobenzonitrile 

Downstream Products

• 1422386-53-5 1-(5-chloro-2-cyanophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 

Relevant academic research and scientific papers

NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

3H-azepines and related systems. Part 5. Photo-induced ring expansions of o-azidobenzonitriles to 3-cyano- and 7-cyano-3H-azepin-2(1H)-ones

Unlike other aryl azides bearing electron-withdrawing ortho-substituents, o-azidobenzonitriles on photolysis in aqueous-tetrahydrofuran yield mixtures of the expected 3-cyano- and the unexpected 7-cyano-3H-azepin-2(1H)-ones. In one instance ring contraction to a 2-azabicyclo[3.2.0]hept-6-ene-3-one is noted. X-ray crystallographic data for 7-cyano- and 4-chloro-7-cyano-3H-azepin-2-one, and for the azabicycloheptenone, are presented.