1561749-40-3Relevant academic research and scientific papers
A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells
Tanaka, Katsunori,Kitadani, Masataka,Tsutsui, Ayumi,Pradipta, Ambara R.,Imamaki, Rie,Kitazume, Shinobu,Taniguchi, Naoyuki,Fukase, Koichi
, p. 1412 - 1418 (2014)
A general probe designed to induce a cascading sequence of reactions on a target protein was efficiently synthesized. The cascading reaction sequence involved (i) ligand-directed azaelectrocyclization with lysine and (ii) the autooxidation-induced release of a fluorescence quencher from the labeled protein. The probe was linked to a cyclic RGDyK peptide to enable the selective visualization of integrin αVβ3 on the surfaces of live cells.
