15619-22-4Relevant academic research and scientific papers
Cyclic nitriles: Diastereoselective alkylations
Fleming, Fraser F.,Gudipati, Subrahmanyam,Zhang, Zhiyu,Liu, Wang,Steward, Omar W.
, p. 3845 - 3849 (2007/10/03)
Diastereoselective alkylations of metalated conformationally locked 4-tert-butylcyclohexanecarbonitrile are highly diastereoselective with magnesium and copper counterions but only modestly diastereoselective with lithium as the counterion. Selective gene
Metalated Nitriles: Halogen - Metal Exchange with α-Halonitriles
Fleming, Fraser F.,Zhang, Zhiyu,Knochel, Paul
, p. 501 - 503 (2007/10/03)
(Equation presented) α-Halonitriles react with organometallic reagents in a facile halogen-metal exchange. The halogen-metal exchange is extremely fast with Grignard and alkyllithium reagents, generating metalated nitriles in situ with aldehyde, ketone, a
