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Usage

Uses

Used in Adhesives Industry:
2-[(2-ethylphenoxy)methyl]oxirane is used as a reactive diluent in epoxy resins for improving the flow and curing properties of adhesive formulations.
Used in Coatings Industry:
2-[(2-ethylphenoxy)methyl]oxirane is used as a reactive diluent in epoxy resins for enhancing the performance and durability of coatings.
Used in Composites Industry:
2-[(2-ethylphenoxy)methyl]oxirane is used as a reactive diluent in epoxy resins for improving the mechanical properties and processability of composite materials.
Used in Organic Synthesis:
2-[(2-ethylphenoxy)methyl]oxirane is used as a building block for the synthesis of various organic compounds due to its epoxide functional group.
Note: Exposure to high levels of 2-[(2-ethylphenoxy)methyl]oxirane can be harmful, causing irritation to the skin, eyes, and respiratory system, and may have potential mutagenic and carcinogenic effects. Therefore, proper safety measures should be taken when handling this chemical.

Upstream product

• 7149-82-8 rac-3-(2-ethylphenoxy)propane-1,2-diol 
• 90-00-6 o-Hydroxyethylbenzene 
• 106-89-8 epichlorohydrin 
• 69076-48-8 1-Chloro-3-(2-ethyl-phenoxy)-propan-2-ol 

Downstream Products

• 1430052-95-1 1-(2′-ethylphenoxy)-2,3-epoxy-propane 
• 1092799-94-4 (R)-3-(2'-ethylphenoxy)-propane-1,2-diol 
• 1092799-92-2 (S)-3-(2'-ethylphenoxy)-propane-1,2-diol 
• 1616790-43-2 1-(2′-ethylphenoxy)-2,3-epoxy-propane 
• 16258-43-8 3-(2-Aethyl-phenoxy)-1-(1-phenoxy-2-propylamino)-propanol-⁽²⁾ 

Relevant academic research and scientific papers

Synthesis of all of the stereoisomers of β3-adrenoceptor antagonist SR 59230 based on the spontaneous resolution of 3-(2-ethylphenoxy)propane-1,2-diol

Racemic 3-(2-ethylphenoxy)propane-1,2-diol 2 has been effectively resolved into (S)- and (R)-enantiomers by a preferential crystallization procedure. Non-racemic diols 2, obtained via a Mitsunobu reaction, have been converted into the non-racemic 1,2-epox

A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors

Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates. Hot pockets: Microtuning of the enzyme active pocket gives a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots, and enhanced activity toward bulky substrates was found.

Antihypertensive indole derivatives of phenoxypropanolamines with β-adrenergic receptor antagonist and vasodilating activity

A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl[i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), β-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with β-adrenergic receptor antagonist and vasodilating action. The structure-activity relationships in these tests are discussed.