1562426-82-7

Basic information

• Product Name: 7-acetyloxy-3-(trifluoromethyl)-2H-1-benzopyran-2-one
• Synonyms: 7-acetyloxy-3-(trifluoromethyl)-2H-1-benzopyran-2-one
• CAS NO: 1562426-82-7
• Molecular Weight: 272.18
• Mol File: 1562426-82-7.mol

Chemical Properties

• CAS DataBase Reference: 7-acetyloxy-3-(trifluoromethyl)-2H-1-benzopyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-acetyloxy-3-(trifluoromethyl)-2H-1-benzopyran-2-one(1562426-82-7)
• EPA Substance Registry System: 7-acetyloxy-3-(trifluoromethyl)-2H-1-benzopyran-2-one(1562426-82-7)

Safety Data

• Hazardous Substances Data: 1562426-82-7(Hazardous Substances Data)

Upstream product

• 10387-49-2 7-acetyloxycoumarin 
• 2926-29-6 Langlois reagent 

Relevant articles and documents

A green and transition-metal-free light-mediated trifluoromethylation reaction of coumarins

A simple, metal- and oxidant-free photo catalysis strategy for the direct trifluoromethylation of coumarins with inexpensive sodium triflinate (Langlois reagent, CF3SO2Na) as the CF3 source under xenon lamp irradiation is described. The reaction proceeds under ambient conditions and affords the corresponding products in moderate yields. The acetone can be used as low-cost radical initiator to generate CF3 radicals from sodium triflinate efficiently.

A mild and fast continuous-flow trifluoromethylation of coumarins with the CF3 radical derived from CF3SO2Na and TBHP

A mild and fast Cu(i)-catalyzed trifluoromethylation of coumarins with CF3SO2Na and TBHP in a continuous-flow reactor has been developed. This method is experimentally simple and carried out under mild conditions, affording the corresponding products in moderate to good yields, and showing wide substrate tolerance. The scale-up flow process results in an isolated yield of 68% and a productivity of 305 mg h-1 of 3-trifluoromethyl-7-diethylamino-4-methyl coumarin when the concentration was increased five-fold. Given these features and the widespread applications of coumarins, this method may find use from laboratory to manufacturing.

Manganese(III)-mediated direct Csp2-H radical trifluoromethylation of coumarins with sodium trifluoromethanesulfinate

Mn(OAc)3-mediated direct Csp2-H radical trifluoromethylation of coumarins with CF3SO2Na (Langlois reagent) to afford selective 3-trifluoromethyl coumarins in moderate to good yields is described. This methodology can also be applied to the trifluoromethylation of quinolinones and pyrimidinones. The Royal Society of Chemistry 2014.