15626-30-9Relevant articles and documents
Enhancement of fluorescent properties of near-infrared dyes using clickable oligoglycerol dendrons
Redy-Keisar, Orit,Huth, Katharina,Vogel, Uwe,Lepenies, Bernd,Seeberger, Peter H.,Haag, Rainer,Shabat, Doron
, p. 4727 - 4732 (2015)
Near-infrared (NIR) fluorescent dyes are gaining increased attention due to their potential to serve as molecular probes for in vivo imaging. Here, we demonstrate that oligoglycerol dendrons effectively enhance the fluorescence properties of an NIR dye by increasing the solubility in water and the prevention of aggregate formation. First- and second-generation oligoglycerol dendrons were conjugated to an NIR dye via a dipolar-cycloaddition (click) reaction. The two new dye conjugates exhibited enhanced NIR fluorescent emission and considerably higher fluorescent quantum yields than the dye alone. The high photostability measured for one of the oligoglycerol-linked dyes, in comparison to commonly used fluorogenic dyes such as Cy5 and Cy7, was validated using fluorescence microscopy of macrophages.
COMPOUNDS AND METHODS FOR OPTICAL SENSING OF ELECTRICAL ACTIVITY IN BIOLOGICAL SYSTEMS
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Paragraph 0090, (2019/08/20)
Disclosed are tethered chromophore compositions comprising a membrane-spanning tether. The compounds can include covalently tethered fluorophore-quencher combinations useful for measuring action potentials and other fast electrical events in cells and tissues.
Charge-Shift Probes of Membrane Potential. Synthesis
Hassner, A.,Birnbaum, D.,Loew, L. M.
, p. 2546 - 2551 (2007/10/02)
We are reporting two general synthetic approaches to a number of (aminostyryl)pyridinium dyes and their heterocyclic analogues which are of interest as electrochromic probes for membrane potential.The two routes which involve palladium-catalyzed coupling or aldol condensation permit considerable structure variations to be introduced in the dyes.Some spectral properties of the dyes are discussed.