1562665-93-3Relevant academic research and scientific papers
Design and synthesis of N1-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors
Monforte, Anna-Maria,Ferro, Stefania,De Luca, Laura,Lo Surdo, Giuseppa,Morreale, Francesca,Pannecouque, Christophe,Balzarini, Jan,Chimirri, Alba
, p. 1459 - 1467 (2014/03/21)
A series of novel N1-aryl-2-arylthioacetamido-benzimidazoles were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Some of them proved to be effective in inhibiting HIV-1 replication at submicromolar and nanomolar concentration acting as HIV-1 non-nucleoside RT inhibitors (NNRTIs), with low cytotoxicity. The preliminary structure-activity relationship (SAR) of these new derivatives was discussed and rationalized by docking studies.
