156270-71-2

Upstream product

• 3601-89-6 Hoffer's chlorosugar 
• 156270-69-8 2-thienylglyoxylic acid thiosemicarbazone 
• 156270-70-1 6-thiophen-2-yl-2H-[1,2,4]triazine-3,5-dione 
• 27623-07-0 6-(2-thienyl)-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one 
• 4075-59-6 2-thiopheneglyoxylic acid 

Relevant academic research and scientific papers

The synthesis of some 5-substituted-6-aza-2'-deoxyuridines

5-(2-Thienyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)- 6-azauracil [VIII] and 5-cyclopropyl-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D- erythro-pentofuranosyl)-6-azauracil [X] were obtained in high yields (93.5% and 81.3% respectively) exclusively as β anomers, by condensation of the corresponding silylated triazine bases with 2-deoxy-3,5-di-O-p-toluoyl-D- erythro-pentosyl chloride in chloroform. After deblocking both nucleosides with sodium methoxide in methanol, 5-(2-thienyl)-6-aza-2'-deoxyuridine [IX] and 5-cyclopropyl-6-aza-2'-deoxyuridine [XI] were obtained. The nucleoside IX was further acetylated, brominated with Br2/CCl4 and deblocked with methanolic ammonia to give 6-aza-5[2-(5-bromothienyl)]-2'-deoxyuridine [XIV].