156274-19-0

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 824-94-2 p-methoxybenzyl chloride 
• 104-47-2 p-methoxybenzylnitrile 
• 82437-65-8 methyl 3-amino-4-(4-methoxyphenyl)-2-thiophenecarboxylate 
• 156274-14-5 4-para-methoxyphenyl-3-(1-pyrrolyl)-2-thiophene-N-pyrrolidinocarboxamide 

Downstream Products

• 373392-92-8 3-(4-hydroxy-phenyl)-thieno[2,3-b]pyrrolizin-8-one 

Relevant academic research and scientific papers

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.

Thienopyrrolizines: New Condensed Triheterocyclic Systems

Cyclization of 3-(1-pyrrolyl)thiophene-2-carboxamide derivatives of methyl 3-(1-pyrrolyl)-2-thiophenecarboxylate afforded imminium salts and resulted in the formation of thienopyrrolizine derivatives.