1562995-71-4

Upstream product

• 350-19-6 ethyl 3,5-difluorobenzoate 
• 73183-34-3 bis(pinacol)diborane 
• 1562995-70-3 ethyl 4-bromo-3,5-difluorobenzoate 
• 1415920-00-1 3,5-difluoro-4-aminobenzoic acid ethyl ester 
• 67567-26-4 4-bromo-2,6-difluoroaniline 
• 5509-65-9 2,6-difluoroaniline 

Downstream Products

• 1562995-30-5 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid 
• 1562995-76-9 ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate 

Relevant academic research and scientific papers

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF

The present invention relates to compounds according to Formula I (Formula I), and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.