156358-30-4Relevant academic research and scientific papers
Mild and selective silicon-mediated access to enantioenriched 1,2-mercaptoamines and β-amino arylchalcogenides
Tanini, Damiano,Borgogni, Cosimo,Capperucci, Antonella
supporting information, p. 6388 - 6393 (2019/04/25)
Metal-free ring opening reactions of activated and unactivated aziridines with different silyl chalcogenides are described. Judicious tuning of the reaction conditions enables the synthesis of chiral enantioenriched N-Ts and N-Boc 1,2-mercaptoamines in good yields from the corresponding aziridines and bis(trimethylsilyl)sulfide. N-Protected and N-H unactivated aziridines are efficiently converted into the corresponding β-arylchalcogeno amines upon treatment with suitable arylchalcogenosilanes. The silicon-mediated ring opening reactions proceed with excellent regioselectivity and stereospecificity, allowing to access a wide array of synthetically and biologically valuable enantioenriched chalcogenoamines.
Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators
Tanini, Damiano,Capperucci, Antonella,Supuran, Claudiu T.,Angeli, Andrea
, p. 516 - 522 (2019/03/29)
A new series of β-aminochalcogenides were designed and synthesized to identify new carbonic anhydrase activator (CAA) agents as novel tools for the management of several neurodegenerative and metabolic disorders which represent a clinical challenge withou
Ring opening of unprotected aziridines by zinc selenolates in a biphasic system
Braga, Antonio L.,Schwab, Ricardo S.,Alberto, Eduardo E.,Salman, Syed M.,Vargas, Josimar,Azeredo, Juliano B.
body text, p. 2309 - 2311 (2009/08/17)
A set of chiral β-seleno amines were prepared by the ring-opening reaction of unprotected aziridines. Under acid conditions diaryl or dialkyl diselenides were reduced by zinc and treated with unprotected aziridines to produce the desired products in good
Straightforward synthesis of non-natural selenium containing amino acid derivatives and peptides
Braga, Antonio L.,Luedtke, Diogo S.,Paixao, Marcio W.,Alberto, Eduardo E.,Stefani, Helio A.,Juliano, Luiz
, p. 4260 - 4264 (2007/10/03)
A series of non-natural selenium-containing amino acid derivatives and peptides have been synthesized, in a flexible and modular strategy. The peptide coupling reaction between N-protected amino acids and chiral ss-seleno amines afforded the desired products in high yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
